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Published on 17:42 GMT

Gene regulatory mechanisms guiding bifurcation of inhibitory and excitatory neuron lineages in the anterior brainstem

The anterior brainstem is a complex neuronal mosaic controlling mood, motivation and movement. These neurons include diverse inhibitory GABAergic and excitatory glutamatergic neurons, some of which are associated with the dopaminergic and serotonergic …

Source: eLife - Label Pending
Published on 13:22 GMT

An Integrative Analysis of Transcriptome Combined with Machine Learning and Single-Cell RNA-Seq for the Common ...

Introduction Inflammatory bowel disease (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), represents a chronic intestinal condition with a high recurrence rate that can lead to varying degrees of damage to the digestive system, …

Source: Dove Medical Press - Neutral
Published on 13:22 GMT

The Comprehensive Analysis of Weighted Gene Co-Expression Network Analysis and Machine Learning Revealed Diagnostic ...

Introduction Breast cancer (BC) is the most frequently diagnosed type of cancer, with approximately 300,590 new cases anticipated.1 In numerous instances, mastectomy serves as the primary treatment for malignant tumours and is thus regarded as a …

Source: Dove Medical Press - Neutral
Published on Apr 9, 2025

Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models

Parkinson’s disease (PD) is a complex condition affecting many facets of motor and non-motor functions, including visual, olfactory, memory and executive functions (Cenci and Björklund, 2020). Due to the widespread features of PD, focusing on changes …

Source: eLife - Label Pending
Published on Apr 9, 2025

Heme’s relevance genuine? Re-visiting the roles of TANGO2 homologs including HRG-9 and HRG-10 in C. elegans

Transport and Golgi Organization 2 (TANGO2) Deficiency Disorder (TDD) is associated with a severe progressive neurodegenerative disease in children and young adults, frequently accompanied by recurrent, life-threatening metabolic crises.1-4 While TANGO2 is …

Source: eLife - Label Pending
Published on Apr 9, 2025

Ameliorative Hypoglycemic Effect of 1-DNJ via Structural Derivatization Followed by Assembly Into Selenized Nanovesicles

Introduction 1-Deoxynojirimycin (1-DNJ), a natural compound from mulberry leaves (Morus alba) and certain fungi like Nocardia strains, is recognized for its hypoglycemic effects and potential to alleviate oxidative stress. Research has shown that 1-DNJ can …

Source: Dove Medical Press - Neutral
Published on Apr 9, 2025

AI Helps Scientists Detect Avocado Oil Adulteration—No Prior Data Needed

Researchers have developed a real-time one-class classification (OCC) method that can detect adulterated edible oils—like avocado oil—without relying on pre-built models or prior knowledge of contaminants. Study: catGRANULE 2.0: accurate predictions of …

Source: AZo Robotics - Neutral
Published on Apr 9, 2025

Layer-by-Layer Engineering of Black Seed Oil Based SNEDDSs (BSO-SNEDDSs): Optimizing Chemical Stability and ...

Introduction Ramipril (Figure 1), an angiotensin-converting enzyme (ACE) inhibitor, plays a pivotal role in the therapeutic landscape for hypertension and congestive heart failure. As an ethyl ester prodrug, ramipril undergoes enzymatic conversion to its …

Source: Dove Medical Press - Neutral
Published on Apr 9, 2025

Selective Deletion of HLA-B, and -C Class I Genes Promotes Immunocompatibility of Humanized Skin Graft Model

Introduction Burns are among the most severe forms of trauma. According to the World Health Organization, approximately 11 million people suffer burns worldwide each year, with 180,000 of these cases resulting in death. [https://www.who.int/ …

Source: Dove Medical Press - Neutral
Published on Apr 8, 2025

Neocortical Layer-5 tLTD Relies on Non-Ionotropic Presynaptic NMDA Receptor Signaling

Synapses continuously remodel in response to neuronal activity. Such synaptic plasticity is thought to underlie information storage (Bliss and Collingridge, 1993; Malenka and Bear, 2004; Nabavi et al., 2014) as well as developmental circuit refinement ( …

Source: eLife - Label Pending
Published on Apr 8, 2025

Isolating Small Extracellular Vesicles from Small Volumes of Blood Plasma using size exclusion chromatography and ...

In recent years, extracellular vesicles (EVs) have garnered significant scientific attention due to their potential as biomarkers and applications in targeted drug delivery [1]. These vesicles are secreted by all cell types and have been detected in …

Source: eLife - Label Pending
Published on Apr 8, 2025

TRPγ regulates lipid metabolism through Dh44 neuroendocrine cells

Nutrient storage is not a simple matter of accumulation but involves a sophisticated network of signals and receptors, feedback loops, and hormonal influences, all choreographed by the brain. The mechanisms involve various tissues and organs, including the …

Source: eLife - Label Pending
Published on Apr 8, 2025

Cholesterol taste avoidance in Drosophila melanogaster

Many types of tastants are beneficial at low concentrations, and harmful at high levels. Examples include minerals such as Na+ and Ca2+ (Zhang, Ni et al. 2013, Lee, Poudel et al. 2018), and fatty acid such as hexanoic acid (Ahn, Chen et al. 2017, Pradhan, …

Source: eLife - Label Pending
Published on Apr 7, 2025

Green Synthesis of Zinc Oxide Nanoparticles as a Promising Nanomedicine Approach for Anticancer, Antibacterial, and Anti-...

Introduction The field of nanotechnology is rapidly advancing, particularly in the synthesis of nanoparticles derived from natural sources.1,2 This approach has the potential to revolutionize several industries, particularly in biomedicine and …

Source: Dove Medical Press - Neutral
Published on Apr 7, 2025

The Selective in vitro Cytotoxicity of Spirulina-Derived Nanoparticles: A Novel Biomimetic Approach to Cancer Therapy

Introduction Cancer treatments like chemotherapy and radiotherapy remain the cornerstone of oncological care, effectively targeting rapidly dividing cells to inhibit tumor growth and progression.1 Nevertheless, these treatments still lack specificity, …

Source: Dove Medical Press - Neutral
Published on Apr 7, 2025

Utility of the Basophil Reactivity Test in the Clinical Management of People with Severe Uncontrolled Asthma

Introduction The clinical management of severe asthma presents an important challenge, especially in people who cannot achieve full control with optimised inhaled therapy and all the measures recommended by clinical practice guidelines.1,2 In these cases, …

Source: Dove Medical Press - Neutral
Published on Apr 7, 2025

Investigating the Therapeutic Potential of Sericin Nanofibers and Rice-Encapsulated Nanosericin for Psoriasis: ...

Introduction Psoriasis is a chronic skin disease caused by immune system dysfunction, involving both innate and adaptive immune responses, which leads to abnormal growth of epidermal cells, particularly keratinocytes.1 The prevalence of psoriasis varies …

Source: Dove Medical Press - Neutral
Published on Nov 7, 2024

Sld3CBD-Cdc45 structural insights into Cdc45 recruitment for CMG complex formation

Eukaryotic chromosomal DNA replication in the cell cycle, a tightly regulated process that ensures precise gene copying, begins with the unwinding of double-stranded DNA (dsDNA) into signal-stranded DNA (ssDNA), including the formation of an active …

Source: eLife - Label Pending
Published on Oct 14, 2024

A Host Enzyme Reduces Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Inactivating Intestinal ...

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a common human affliction. Its global prevalence, currently about 25%, has been increasing (Diehl and Day, 2017; Fan et al., 2017; Younossi et al., 2018). MASLD may progress from …

Source: eLife - Label Pending

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Published on April 10, 2025 - 20:01 GMT

Shuttle Pharma Developing Pretreatment Diagnostic Blood Tests for Prostate Cancer, Files Provisional Patent for PSMA ...

Filing provisional patent application with the USPTO entitled “PSMA-Targeted PARP Inhibitor conjugates for Precision Cancer Therapy” key to advancement of Diagnostic and Therapeutic programs Dr. Alan Kozikowski, internationally acclaimed pioneer in the …

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Published on April 10, 2025 - 13:30 GMT

SCW.AI and Sequence Inc. Join Forces to Accelerate Pharma's Digital Transformation Journey

SCW.AI and Sequence Inc. partner to revolutionize pharma manufacturing with digital solutions and hands-on training for operational excellence. ATLANTA, GA, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- SCW.AI, a global leader in life …

Distribution channels: Business & Economy, Companies ...

Published on April 10, 2025 - 16:24 GMT

Actinium Pharmaceuticals, Inc. Sued for Securities Law Violations – Contact Levi & Korsinsky Before May 27, 2025 to ...

NEW YORK, April 10, 2025 (GLOBE NEWSWIRE) -- Levi & Korsinsky, LLP notifies investors in Actinium Pharmaceuticals, Inc. ("Actinium" or the "Company") (NYSE: ATNM) of a class action securities lawsuit. CLASS DEFINITION: The lawsuit …

Distribution channels: Consumer Goods, Law ...
Published on April 10, 2025 - 13:30 GMT

Microencapsulation Market to Reach $24.07 Billion by 2029, Driven by Pharma & Food Innovations – BASF, DSM-Firmenich, ...

Delray Beach, FL, April 10, 2025 (GLOBE NEWSWIRE) -- According to the latest research report Microencapsulation Market published by MarketsandMarkets™, The global microencapsulation market size was valued at $15.38 billion in 2024 and is projected to reach …

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Published on April 10, 2025 - 12:30 GMT

Inozyme Pharma Announces JBMR Plus Publication Demonstrating Real-World Impact of ENPP1 Deficiency

- Data from the largest retrospective analysis of ENPP1 Deficiency provides insights into the evolution of the disease’s serious cardiovascular and musculoskeletal complications - - Findings highlight the urgent need for early and improved diagnosis, care …

Distribution channels: Healthcare & Pharmaceuticals Industry, Media, Advertising & PR ...
Published on April 10, 2025 - 11:30 GMT

Quoin Pharmaceuticals Releases Second Episode of its “Living with Netherton” Series, as part of its ongoing NETHERTON ...

Episode Highlights a Truly Remarkable Patient Story Spanning 79 Years Video features 79-year-old Norma Coles, believed to be among the earliest individuals ever evaluated for Netherton Syndrome and is available on the company’s NETHERTON NOW website …

Distribution channels: Culture, Society & Lifestyle, Healthcare & Pharmaceuticals Industry ...
Published on April 10, 2025 - 12:00 GMT

Ottimo Pharma Strengthens Board with Appointment of Roger Dansey, M.D. to its Board of Directors

Dansey, a former senior executive at Pfizer and Seagen, Inc., brings extensive experience in immuno-oncology and drug development Board appointment reinforces Company’s commitment to advancing Jankistomig, a one-of-a-kind PD-1/VEGFR2 dual paratopic …

Distribution channels: Companies, Healthcare & Pharmaceuticals Industry ...
Published on April 10, 2025 - 12:00 GMT

Imbria Pharmaceuticals Raises $57.5M Series B Financing Round and Appoints Alvin Shih, MD as CEO

– Led by new investor Deep Track Capital, with participation from AN Ventures, Catalio Capital Management, Cytokinetics, Inc. and existing investors RA Capital Management and SV Health Investors – – Proceeds to support advancement of ninerafaxstat for the …

Distribution channels: Banking, Finance & Investment Industry, Companies ...

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Published on April 10, 2025 - 21:09 GMT

Transcend Biologics Launches TropoVet™ PRP: Advancing Regenerative Care in Veterinary Medicine

Transcend Biologics launches TropoVet™ PRP, a one-step regenerative therapy that enhances healing and recovery for pets using advanced platelet technology. DALLAS, TX, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- Transcend Biologics, a …

Distribution channels: Healthcare & Pharmaceuticals Industry ...
Published on April 10, 2025 - 20:58 GMT

Dark Tourism as Therapy: Dr. Chad Scott Explores the Power of Travel in Beyond the Darkness

A therapist and travel writer explores dark tourism sites worldwide, revealing how journeys through tragedy can inspire healing, strength, and meaning. DULUTH, MN, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- Dr. Chad Scott isn’t your …

Distribution channels: Book Publishing Industry, Culture, Society & Lifestyle ...
Published on April 10, 2025 - 20:15 GMT

CAL ACE Nursing Academy Featured on Forbes.com for Excellence in CNA Training

CAL ACE Nursing Academy, featured on Forbes.com, offers top CNA training with unique pinning ceremonies and nearly 500 five-star reviews in just over 3 years! SILICON VALLEY, CA, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- CAL ACE …

Distribution channels: Culture, Society & Lifestyle, Education ...
Published on April 10, 2025 - 20:01 GMT

Bexa™ Project Expands Breast Cancer Screening Access in Rural Texas

LUBBOCK, TEXAS, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- According to the most recent CDC report, more than 42,000 women in the U.S. lost their lives to breast cancer in 2022. Early detection of breast cancer significantly reduces …

Distribution channels: Education, Healthcare & Pharmaceuticals Industry ...
Published on April 10, 2025 - 19:40 GMT

Helping Hands, Healing Hair: Hair We Share's United Salons of America Fundraiser Returns

Join Salons Across the Nation in Supporting Hair Loss Patients Through Hair We Share's Inspiring Annual Event JERICHO, NY, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- Hair We Share proudly announces the Second Annual United Salons of …

Distribution channels: Beauty & Hair Care, Companies ...
Published on April 10, 2025 - 19:30 GMT

Sutter Health and SCAN Group Announce Strategic Collaboration to Enhance Medicare Advantage Services in Northern ...

NORTHERN CA AND LONG BEACH, CA, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- Sutter Health (Sutter), a not-for-profit integrated healthcare system, and SCAN Group (SCAN), a diversified not-for-profit healthcare company, announce a long- …

Distribution channels: Business & Economy, Companies ...
Published on April 10, 2025 - 19:27 GMT

Hormonal Fluctuations May Influence ADD Symptoms Differently in Women and Men, Says Gulfport Physician

GULFPORT, LA, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- Attention Deficit Disorder (ADD) presents differently across individuals, but growing evidence suggests that hormonal fluctuations play a significant role in how symptoms manifest— …

Distribution channels: Culture, Society & Lifestyle, Healthcare & Pharmaceuticals Industry ...
Published on April 10, 2025 - 19:27 GMT

AEBC Calls for Action on Accessibility & Inclusion Ahead of the 2025 Federal Election

Four key questions on accessibility and inclusion that voters need to ask their local political candidates CANADA, April 10, 2025 /⁨EINPresswire.com⁩/ -- With Canada's 2025 Federal Election set for April 28, the Alliance for Equality of Blind …

Distribution channels: Culture, Society & Lifestyle, Healthcare & Pharmaceuticals Industry ...
Published on April 10, 2025 - 19:17 GMT

Enhancing Lives Through Compassionate Care: TMF Health Quality Institute Contributes to Divine Canines

AUSTIN, TX, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- In March of this year, TMF Health Quality Institute donated $10,000 to Divine Canines, a local nonprofit organization that trains dogs and handlers to provide canine therapy for …

Distribution channels: Healthcare & Pharmaceuticals Industry ...
Published on April 10, 2025 - 19:13 GMT

(OTC: CATV) Reports Nearly $500K in Q4 Revenue, eliminates $830K in Debt, and Appoints CEO to Lead Bold Transformation

Susan Ward joins as CEO to spearhead Opus Holdings’ into a high-growth business incubator model after pivotal year of restructuring and Share dilution reduction MIAMI, FL, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- Opus Holdings, Inc. ( …

Distribution channels: Banking, Finance & Investment Industry, Companies ...
Published on April 10, 2025 - 19:06 GMT

Link Between Traumatic Brain Injury and Post-Traumatic Stress Disorder Gains Greater Clinical Attention

METAIRIE, LA, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- Clinical findings are reinforcing a significant correlation between Traumatic Brain Injury (TBI) and Post-Traumatic Stress Disorder (PTSD)—two conditions often treated …

Distribution channels: Culture, Society & Lifestyle, Healthcare & Pharmaceuticals Industry ...
Published on April 10, 2025 - 17:58 GMT

As Federal Cuts Threaten Community Services, The Impact Collaborative Appoints Dr. Claire Wang as Executive Director

IC appoints Dr. Claire Wang as Exexcutive Director , ushering in a new era of innovation, equity, and data-driven transformation for the social impact sector. NEW YORK, NY, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- With community-based …

Distribution channels: Business & Economy, Culture, Society & Lifestyle ...
Published on April 10, 2025 - 17:52 GMT

Omni Aesthetics Introduces OmniWave Soundwave Therapy: A New Era in Non-Invasive Pain and Injury Treatment

Omni Aesthetics launches OmniWave Soundwave Therapy to boost healing, ease pain, and enhance regenerative treatments—non-invasive and highly effective. OAKLAND, NJ, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- Omni Aesthetics, a leading …

Distribution channels: Culture, Society & Lifestyle, Healthcare & Pharmaceuticals Industry ...
Published on April 10, 2025 - 17:19 GMT

Aurora Dentist Dr. John K. Zalesky Featured for Expertise in Gum Disease Symptoms and Prevention

Highlights Early Gum Disease Symptoms and Prevention Tips AURORA, CO, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- Residents of Aurora, CO wondering how to tell if they have gum disease can now turn to expert insight from Dr. John K. …

Distribution channels: Culture, Society & Lifestyle, Education ...
Published on April 10, 2025 - 17:16 GMT

Rhombus University Renews CCAPP Approval Through 2028

Rhombus University’s renewed CCAPP approval affirms its leadership in addiction counseling and behavioral health education. LA MESA, CA, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- Rhombus University is proud to announce the renewal of …

Distribution channels: Companies, Education ...
Published on April 10, 2025 - 17:14 GMT

CMMC Level 2 Assessment with ecfirst, A DoD Authorized C3PAO

Ensuring Cyber Defense Resilience as the CMMC Framework Becomes Mandatory WAUKEE, IA, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- With the Cybersecurity Maturity Model Certification (CMMC) program now fully operational, ecfirst is …

Distribution channels: Companies, Healthcare & Pharmaceuticals Industry ...
Published on April 10, 2025 - 17:05 GMT

Avertium Recognized with Microsoft Verified Managed XDR Solution Status

Avertium's Fusion MXDR for Microsoft offering has achieved Microsoft Verified Managed Extended Detection and Response (MXDR) solution status. KNOXVILLE, TN, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- Avertium's Fusion MXDR for …

Distribution channels: Banking, Finance & Investment Industry, Healthcare & Pharmaceuticals Industry ...
Published on April 10, 2025 - 17:00 GMT

DOLL AMIR & ELEY EARNS CHAMBERS CALIFORNIA SPOTLIGHT RANKING

LOS ANGELES, CA, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- Doll Amir & Eley LLP announced today that the firm has been recognized in the inaugural Chambers California Spotlight Guide for 2025. Distinctions from Chambers Spotlight …

Distribution channels: Healthcare & Pharmaceuticals Industry, Law ...
Published on April 10, 2025 - 17:00 GMT

Cloudester Software Launches Advanced Quality Management System (AQMS) to Enhance Compliance and Operational Efficiency

Advanced Quality Management System (AQMS) is designed to streamline quality control, audits, and regulatory compliance across various industries. NEW YORK, NY, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- Cloudester Software, a leading …

Distribution channels: Chemical Industry, Healthcare & Pharmaceuticals Industry ...
Published on April 10, 2025 - 17:00 GMT

HiPaaS Inc. Partners with Databricks to Enhance Healthcare Data Interoperability and AI-Powered Insights

New Healthcare Data Integration and Analytics Solution Will Enable Providers and Payers to Leverage AI for Improved Patient Outcomes. PLEASANTON, CA, UNITED STATES, April 10, 2025 /⁨EINPresswire.com⁩/ -- HiPaaS Inc., a leading healthcare-focused …

Distribution channels: Banking, Finance & Investment Industry, Companies ...

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