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Published on Apr 4, 2025

Novartis' lipid-lowering drug Leqvio clears reimbursement hurdle on 1st attempt

Novartis' twice-yearly lipid-lowering subcutaneous injection Leqvio (inclisiran) has passed the Pharmaceutical Reimbursement Evaluation Committee (PREC) on its first challenge. However, it was decided to rediscuss Ipsen's Bylvay (odevixibat), which …

Source: Korea Biomedical Review - Neutral
Published on Apr 3, 2025

New injectable drug offers up to 93.9% reduction in heart cholesterol

A new clinical trial has yielded promising results for Lepodisiran, an experimental drug from U.S. pharmaceutical company Eli Lilly to reduce cardiovascular disease. The injectable drug significantly reduced levels of lipoprotein(a) [Lp(a)], a hereditary …

Source: Ynet - Uncategorized
Published on Apr 3, 2025

Squid-Inspired Drug Delivery

Here’s how researchers took lessons from cephalopods to develop a new capsule that can deliver drugs, including insulin and siRNA, orally Stephanie Vine | 04/03/2025 | 4 min read | News Researchers at MIT, Brigham and Women’s Hospital, and Novo …

Source: The Medicine Maker - Neutral
Published on Apr 1, 2025

An Experimental Drug Just Slashed Genetic Heart Risk by 94%

Credit: AI-generated illustration by ChatGPT 4o. By the time Monte Wooden had his first heart attack, nothing about his lifestyle explained it. He didn’t smoke. His blood pressure was normal. He had been taking statins to manage moderately elevated …

Source: ZME Science - Neutral
Published on Apr 1, 2025

Large pharma drug licensing from China hits high at 28% in 2024

Licensing agreements for Chinese drug candidates have surged, with large pharma in-licensing 28% of innovator drugs from Chinese biopharma companies in 2024. The total deal value of innovator drug licensing agreements involving Chinese biopharma licensors …

Source: Pharmaceutical Technology - Neutral
Published on Mar 31, 2025

Millions Share a Deadly Genetic Heart Risk. This Experimental Drug Could Be a Game Changer

An experimental drug could be game-changing for millions of Americans with a higher genetic risk of cardiovascular disease. In clinical trial data published over the weekend, Eli Lilly’s lepodisiran was found to dramatically reduce people’s levels of a …

Source: Gizmodo - Neutral
Published on Mar 31, 2025

Lepodisiran drug shows unprecedented 94% drop in heart disease risk factor: Study

Eli Lilly and Company announced encouraging results from a Phase 2 trial of lepodisiran, an investigational therapy aimed at reducing levels of lipoprotein(a) [Lp(a)], a genetic risk factor associated with heart disease. The ALPACA study, which included …

Source: Interesting Engineering - New York - Neutral
Published on Mar 31, 2025

Eli Lilly's Cholesterol Drug Reduces Genetic Heart Disease Risk Factor By 93.9%

Eli Lilly And Co LLY, on Sunday, announced positive Phase 2 results for lepodisiran, an investigational small interfering RNA (siRNA) therapy designed to lower the production of lipoprotein(a) [Lp(a)], a genetically inherited risk factor for heart disease. …

Source: Benzinga - Neutral
Published on Apr 2, 2025

Generation Bio to Present at the Needham 24th Annual Virtual Healthcare Conference

CAMBRIDGE, Mass., April 02, 2025 (GLOBE NEWSWIRE) -- Generation Bio Co. (Nasdaq:GBIO), a biotechnology company working to change what’s possible for people living with T cell-driven autoimmune diseases, announced that Geoff McDonough, M.D., president and …

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Published on Apr 4, 2025

Small-molecule activation of TFEB alleviates Niemann–Pick disease type C via promoting lysosomal exocytosis and ...

TFEB and TFE3 are identified as key transcription factors regulating lysosome and autophagy biogenesis (Sardiello et al., 2009). To investigate the role of TFEB/TFE3 in cellular cholesterol levels in NPC1 cells, HeLa cells were treated with U18666A (2. …

Source: eLife - Label Pending
Published on Apr 4, 2025

Sigma-1 Receptor Rescues Autophagy Through AMPK/mTOR Signaling Pathway in Sepsis-Induced Acute Kidney Injury

Introduction Acute kidney injury (AKI) is a prevalent medical condition that encompasses various fields of study. Its characteristic feature is a rapid decline in kidney function, primarily indicated by a sudden drop in glomerular filtration rate. This …

Source: Dove Medical Press - Neutral
Published on Apr 3, 2025

Unraveling resistance to CDK4/6 inhibitors in ovarian cancer

Ovarian cancer, a leading cause of death among gynecological malignancies, has a poor prognosis and low 5-year survival rate, necessitating new therapeutic strategies. CDK4/6 inhibitors show promise but their efficacy varies, highlighting the need for …

Source: Medical News - Neutral
Published on Apr 3, 2025

Around the Helix: Cell and Gene Therapy Company Updates – April 2, 2025

The cell and gene therapy sectors are growing exponentially, with new players emerging daily and much progress being made both in and out of the lab. CGTLive®’s Around the Helix is your chance to catch up with the latest news in cell and gene therapies, …

Source: CGTLive - Neutral
Published on Apr 2, 2025

AIRNA Closes $155M Series B Round to Fund ATTD Trial, Build Pipeline

RNA editing therapy developer AIRNA has closed on an oversubscribed $155 million Series B financing it said will help it advance its lead program targeting Alpha-1 antitrypsin deficiency (AATD) into a Phase I/II trial this year. The financing comes …

Source: Genetic Engineering & Biotechnology News -New York - Label Pending
Published on Apr 1, 2025

Molecular Requirements for C. elegans Transgenerational Epigenetic Inheritance of Pathogen Avoidance

C. elegans in the wild is found primarily in rotting fruit, where a range of bacterial species serve as abundant food sources (Félix & Duveau, 2012). About a third of these species are of the Pseudomonas family (Samuel et al, 2016), and many of those …

Source: eLife - Label Pending
Published on Apr 1, 2025

FDA Activity Recap: March 2025 Features FDA Approvals in Hemophilia, ATTR Amyloidosis, and More

Last month, March 2025, the CGTLive® team was diligently tracking the FDA's activities related to the development of cell and gene therapies for the treatment of rare, complex, and otherwise challenging diseases and disorders. The agency has continued …

Source: CGTLive - Neutral
Published on Apr 1, 2025

TRIM4 Influences hnRNPDL Degradation via Ubiquitin Pathway, Impacting Sensitivity to CDK4/6 Inhibitors in Ovarian Cancer

Ovarian cancer remains one of the most challenging gynecological malignancies, notorious for its late-stage diagnosis and poor survival rates. Despite ongoing advancements in oncological therapies, the urgent pursuit for innovative treatment strategies …

Source: Bioengineer.org - Label Pending
Published on Apr 1, 2025

Which Biopharma Startups Made the Cut for INVEST Pitch Perfect?

The finalists for the biopharma track of INVEST Pitch Perfect have been selected. At the INVEST Pitch Perfect boutique healthcare investor conference, six biopharma companies will present their approaches to infectious disease, the track theme this year. …

Source: MedCity News - Neutral
Published on Apr 2, 2025

Role of EFNAs in Shaping the Tumor Immune Microenvironment and Their Impact on Pancreatic Adenocarcinoma Prognosis

Introduction Pancreatic cancer is a highly malignant tumor of the digestive tract. Due to its insidious location, atypical early clinical symptoms, and rapid disease progression, the efficacy of various treatments are poor, and the five-year survival rate …

Source: Dove Medical Press - Neutral

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Published on April 4, 2025 - 20:30 GMT

ORIC Pharmaceuticals Reports Inducement Grants under Nasdaq Listing Rule 5635(c)(4)

SOUTH SAN FRANCISCO, Calif. and SAN DIEGO, April 04, 2025 (GLOBE NEWSWIRE) -- ORIC Pharmaceuticals, Inc. (Nasdaq:ORIC), a clinical stage oncology company focused on developing treatments that address mechanisms of therapeutic resistance, today announced …

Distribution channels: Technology ...
Published on April 4, 2025 - 20:05 GMT

Syndax Pharmaceuticals Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4)

NEW YORK, April 04, 2025 (GLOBE NEWSWIRE) -- Syndax Pharmaceuticals (Nasdaq: SNDX), a commercial-stage biopharmaceutical company developing an innovative pipeline of cancer therapies, today announced that on April 1, 2025 the Company granted inducement …

Distribution channels: Healthcare & Pharmaceuticals Industry ...

Published on April 4, 2025 - 20:01 GMT

NewAmsterdam Pharma Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

NAARDEN, the Netherlands and MIAMI, April 04, 2025 (GLOBE NEWSWIRE) -- NewAmsterdam Pharma Company N.V. (Nasdaq: NAMS or “NewAmsterdam” or the “Company”), a late-stage, clinical biopharmaceutical company developing oral, non-statin medicines for patients …

Distribution channels: Healthcare & Pharmaceuticals Industry ...
Published on April 4, 2025 - 12:33 GMT

Global Bipolar Disorder Market Size, Growth, Industry Trends | Emergen Research

rising initiative by government institutes to increase the awareness, and technological advancements treatment options and diagnostic tools. VANCOUVER, BRITISH COLUMBIA, CANADA, April 4, 2025 /⁨EINPresswire.com⁩/ -- Emergen Research's latest …

Distribution channels: Healthcare & Pharmaceuticals Industry ...

Published on April 4, 2025 - 20:00 GMT

ATNM INVESTOR ALERT: Bronstein, Gewirtz & Grossman LLC Announces that Actinium Pharmaceuticals, Inc. Investors with ...

NEW YORK, April 04, 2025 (GLOBE NEWSWIRE) -- Attorney Advertising -- Bronstein, Gewirtz & Grossman, LLC, a nationally recognized law firm, notifies investors that a class action lawsuit has been filed against Actinium Pharmaceuticals, Inc. (“Actinium” …

Distribution channels: Consumer Goods, Law ...
Published on April 4, 2025 - 18:50 GMT

Mary Kutter’s Viral Anthem “Devil Wore A Lab Coat” Strikes a Nerve with America—and the World is Listening

Country singer Mary Kutter goes viral with powerful anthem on pharma crisis, giving a voice to rural America’s pain and resilience. NASHVILLE, TN, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- In a cultural moment where heartland voices …

Distribution channels: Culture, Society & Lifestyle, Healthcare & Pharmaceuticals Industry ...
Published on April 5, 2025 - 02:23 GMT

CMS releases final rule for 2026 Medicare Advantage, prescription drug plans

The Centers for Medicare & Medicaid Services April 4 finalized changes to the Medicare Advantage and prescription drug programs for contract year 2026. The rule finalizes proposed clarifications requiring MA and Part D plans to honor medical necessity …

Distribution channels: Healthcare & Pharmaceuticals Industry
Published on April 4, 2025 - 14:19 GMT

Cardiac Safety Services Market to Reach USD 510.7 Billion by 2033, Driven by Rising Cardiovascular Disease Cases

The global Cardiac Safety Services Market is poised for significant growth, with market size expected to increase from an estimated USD 310.1 billion in 2024 VANCOUVER, BRITISH COLUMBIA, CANADA, April 4, 2025 /⁨EINPresswire.com⁩/ -- The Global …

Distribution channels: Healthcare & Pharmaceuticals Industry ...

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Published on April 4, 2025 - 23:58 GMT

FutureFamilyAI.com New website uses DNA and AI to help people improve finding compatible partners

"FutureFamilyAI combines AI and genetic science to revolutionize matchmaking and family planning, ensuring healthier relationships and future generations." NEW YORK CITY, NY, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- …

Distribution channels: Business & Economy, Culture, Society & Lifestyle ...
Published on April 4, 2025 - 22:15 GMT

Trilogy Expands Mental Healthcare Services on Chicago’s Northwest Side

Nonprofit Mental and Behavioral Healthcare Org Grows to Meet Increasing Demand thanks to Critical Funds from Cook County Health Office of Behavioral Health CHICAGO, IL, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- Trilogy, a nonprofit …

Distribution channels: Business & Economy, Companies ...
Published on April 4, 2025 - 20:20 GMT

Affordable Dental IT Support Now Available for On-Site and Remote Services in Los Angeles and Ventura Counties

Professional, HIPAA-compliant Dental IT Support now available across LA and Ventura with special rates for new clients. LOS ANGELES, CA, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- As dental practices become more digitized and patient data …

Distribution channels: Building & Construction Industry, Business & Economy ...
Published on April 4, 2025 - 19:57 GMT

Pittsburgh-Based Greer Foundation to Host Fundraiser Helping Families Battling Childhood Cancer

A fundraiser supporting families battling childhood cancer is scheduled to take place Saturday April 12th at Helltown Taproom Butler. PITTSBURGH, PA, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- Lunch & Libations, a fundraiser …

Distribution channels: Healthcare & Pharmaceuticals Industry ...
Published on April 4, 2025 - 19:53 GMT

allGeo Strengthens Homecare Agency Operations with Its End-to-End Electronic Visit Verification Platform

allGeo strengthens its EVV system for homecare, streamlining caregiver scheduling, payroll, compliance, and safety for improved operational efficiency. PALO ALTO, CA, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- allGeo, a service by Abaqus …

Distribution channels: Building & Construction Industry, Healthcare & Pharmaceuticals Industry ...
Published on April 4, 2025 - 19:00 GMT

SCAN Makes Fortune 100 Best Companies to Work For List

LONG BEACH, CA, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- SCAN Health Plan (SCAN), one of the nation's largest and fastest growing not-for-profit Medicare Advantage health plans, is proud to announce Fortune* and Great Place to Work have …

Distribution channels: Companies, Healthcare & Pharmaceuticals Industry ...
Published on April 4, 2025 - 18:50 GMT

Mary Kutter’s Viral Anthem “Devil Wore A Lab Coat” Strikes a Nerve with America—and the World is Listening

Country singer Mary Kutter goes viral with powerful anthem on pharma crisis, giving a voice to rural America’s pain and resilience. NASHVILLE, TN, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- In a cultural moment where heartland voices …

Distribution channels: Culture, Society & Lifestyle, Healthcare & Pharmaceuticals Industry ...
Published on April 4, 2025 - 18:41 GMT

SNP Alliance Statement on the Senate Confirmation of CMS Administrator Dr. Mehmet Oz

WASHINGTON, DC, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- The Special Needs Plan Alliance is a bipartisan organization representing 70% of all Medicare Advantage Special Needs Plans (SNPs), Institutional SNPs, Chronic Condition SNPs, Dual SNPs, …

Distribution channels: Healthcare & Pharmaceuticals Industry, Insurance Industry ...
Published on April 4, 2025 - 18:15 GMT

HACQAH Launches NoiseCure to Address Acoustic Wellness for Healthcare

New division focuses on evidence-based acoustic design to enhance patient comfort and staff well-being. DALLAS, TX, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- HACQAH, a national leader in healthcare-focused art and signage, has announced …

Distribution channels: Building & Construction Industry, Companies ...
Published on April 4, 2025 - 17:53 GMT

MedCenter: Powered by ExperCARE Extends Hours to Provide Convenient, Accessible Healthcare for Alabama Families

Northport, Tuscaloosa, Demopolis, Fayette, and Northriver locations now offer extended hours to serve the communities’ diagnostic and preventative health needs TUSCALOOSA, AL, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- MedCenter: Powered …

Distribution channels: Healthcare & Pharmaceuticals Industry ...
Published on April 4, 2025 - 17:48 GMT

Urgent Care Northwest: Powered by ExperCARE Extends Hours to Provide Convenient, Accessible Healthcare in Alabama

The Jasper, Alabama location now offers evening and weekend hours to serve the community's diagnostic and preventative health needs. JASPER, AL, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- Urgent Care Northwest: Powered by ExperCARE, …

Distribution channels: Healthcare & Pharmaceuticals Industry ...
Published on April 4, 2025 - 17:45 GMT

Ozempic Face vs. A Facelift: The Truth Behind the Newest Aging Dilemma

SMITHTOWN, NY, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- The rise of weight-loss medications like Ozempic, Wegovy, and Mounjaro has transformed bodies—and unexpectedly, faces. As thousands shed pounds, a new aesthetic concern is gaining …

Distribution channels: Culture, Society & Lifestyle, Healthcare & Pharmaceuticals Industry ...
Published on April 4, 2025 - 17:30 GMT

Private Healthcare in the London: How Chase Lodge Hospital Reshapes Patient Care with Advanced Technologies

Chase Lodge Hospital is revolutionizing private healthcare in London by integrating advanced technologies to enhance patient care. LONDON, ENGLAND, UNITED KINGDOM, April 4, 2025 /⁨EINPresswire.com⁩/ -- Chase Lodge Hospital takes the lead in …

Distribution channels: Healthcare & Pharmaceuticals Industry, Insurance Industry ...
Published on April 4, 2025 - 17:24 GMT

ACHS Promotes Amanda Sparks to Director of Student Accounts & Business Operations

ACHS promotes Amanda Sparks to Director of Student Accounts & Business Ops, recognizing her leadership in financial services and commitment to student success. PORTLAND, OR, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- The American …

Distribution channels: Banking, Finance & Investment Industry, Beauty & Hair Care ...
Published on April 4, 2025 - 17:23 GMT

Rhode Island Estate Planning Attorney to Deliver Innovative Care Plan at Alzheimer’s Association Conference

EAST GREENWICH, RI, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- McCarthy Law, a leading estate planning firm in Rhode Island, is proud to announce that Founding Attorney Samantha McCarthy Jarvis will share strategic care tools for aging …

Distribution channels: Conferences & Trade Fairs, Culture, Society & Lifestyle ...
Published on April 4, 2025 - 17:13 GMT

ACHS Appoints Dr. Patricia Kaufman as Dean of Integrative Health and Nutrition

ACHS promotes Dr. Patricia Kaufman to Dean of Integrative Health & Nutrition, highlighting her impact on functional nutrition, research, and student success. PORTLAND, OR, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- The American …

Distribution channels: Beauty & Hair Care, Consumer Goods ...
Published on April 4, 2025 - 16:46 GMT

Cleveland Clinic Joins U.S. Clinical Trial of VERTICA - a Non-Invasive Erectile Dysfunction Treatment

Cleveland Clinic Joins U.S. Clinical Trial of VERTICA - a Non-Invasive Erectile Dysfunction Treatment Already Used by Over 7,000 Men Worldwide LONDON, UNITED KINGDOM, April 4, 2025 /⁨EINPresswire.com⁩/ -- OHH-MED Medical Ltd., a global leader in …

Distribution channels: Business & Economy, Healthcare & Pharmaceuticals Industry ...
Published on April 4, 2025 - 16:42 GMT

Exploring the Broader Role of Vitamin D in Physical and Mental Health

METAIRIE, LA, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- While commonly referred to as the "sunshine vitamin," vitamin D plays far more complex roles in the human body than previously understood. Research continues to highlight its …

Distribution channels: Culture, Society & Lifestyle, Healthcare & Pharmaceuticals Industry ...
Published on April 4, 2025 - 16:29 GMT

Arizona Dryout Unveils New Website to Streamline Customer Access and Service Information

Arizona Dryout launches a new website to connect clients with expert restoration services and resources. TUCSON, AZ, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- Arizona Dryout, a provider of water and fire damage restoration services in …

Distribution channels: Business & Economy, Companies ...
Published on April 4, 2025 - 16:18 GMT

Oculus Eyecare Turns 12: A Celebration of Independent Eyewear and Community

Seattle’s premier optometry practice and optical boutique, Oculus Eyecare, is celebrating a major milestone—12 years in business. SEATTLE , WA, UNITED STATES, April 4, 2025 /⁨EINPresswire.com⁩/ -- Seattle’s premier optometry practice and optical …

Distribution channels: Beauty & Hair Care, Consumer Goods ...